Oral Mucosal Endotoxin Tolerance Induction in Chronic Periodontitis

Induction of RelB participates in endotoxin tolerance.

Using a THP-1 human promonocyte model of endotoxin tolerance that simulates the sepsis leukocyte phenotype, we previously showed that tolerant cells remain responsive to LPS endotoxin with degradation of IkappaB in the cytosol and nuclear translocation and accumulation of p50 and p65 NF-kappaB transcription factors. Despite this, endotoxin-inducible NF-kappaB-dependent innate immunity genes, li...

Specific oral tolerance induction in food allergy.

Specific oral tolerance in food allergy can be induced by oral administration of the offending food, starting with very low dosages, gradually increasing the daily dosage up to an amount equivalent to a usually relevant dose for daily intake, followed up by a daily maintenance dose. Unfortunately, the body of scientific evidence concerning specific oral tolerance induction (SOTI) is still rathe...

Identification of Oral Strains of Lactobacillus species in Patients with Chronic Periodontitis and Healthy Individuals

Background and aim: Chronic periodontitis has been defined as an infectious disease resulting in inflammation within the dental supporting tissue, progressive attachment loss and bone resorption. Nowadays, with increasing microbial resistance, bacterial therapy is an alternative to prevent inflammatory diseases of the oral cavity, which regulates oral microbiota and eliminating pathogenic bac...

Endotoxin Tolerance. I. Its Induction by Experimental Pyelonephritis.

Effects of Dentifrice Containing 2% Atorvastatin and Oral Ascorbic Acid in Treatment of Chronic Periodontitis

Background and purpose: Ascorbic acid is an important antioxidant and its depletion is a risk factor for periodontal diseases. This study aimed to evaluate the effect of 2% atorvastatin dentifrice and ascorbic acid on improving clinical periodontal parameters in patients with chronic periodontitis. Materials and methods: This clinical trial included 72 patients with moderate and severe chronic...